Product Introduction
Tetrabutylammonium fluoride trihydrate is a mild base and an economical fluorinating agent commonly used in the synthesis of 6-fluoropurine and its derivatives. It is also an essential pharmaceutical intermediate with notable biological activity. Furthermore, it plays a critical role as an intermediate in the synthesis of sulfur-based compounds.
Product Properties
|
Product Name |
Tetrabutylammonium fluoride trihydrate(TBAF·3H2O) |
|
CAS NO.: |
87749-50-6 |
|
Molecular Formula |
C16H36FN·3(H2O) |
|
Structural Formula |
|
|
Molecular Weight |
315.51 |
|
Assay: |
98.0% min |
|
Appearance: |
White to yellow paste solid |
|
Melting point: |
62℃-63℃ |
|
Solubility: |
It can be well dissolved in water, but also soluble in a variety of organic solvents |
Product Application
Tetrabutylammonium fluoride trihydrate (TBAF trihydrate) It is mainly used as phase transfer catalyst in organic synthesis chemistry such as halogen substitution reaction, REDOX reaction, N-alkylation, carbene dichloride and other reactions.It is also used in the following aspects:
Deprotection of silyl protective groups: TBAF trihydrate is a highly efficient reagent that selectively removes silyl protective groups used in organic synthesis. This function is particularly important in the synthesis of complex organic molecules.
Fluorinating agent in organic synthesis: While TBAF trihydrate does not directly provide fluorine atoms, it participates in reactions that may indirectly lead to fluorination. For instance, it is used in the synthesis of 6-fluoropurine and its derivatives, which are biologically active pharmaceutical intermediates.
Catalysis of silicon-based reactions: TBAF trihydrate catalyzes reactions involving various silicon-containing compounds, promoting the transformation or recombination of silicon groups.
Use as an organic base: Due to its mild alkalinity, TBAF trihydrate is suitable for organic synthesis steps where controlled acid-base conditions are required.
Product Packaging & Storage
Packaging and Shipping
82% concentration: plastic drum or cardboard drum with pallets, net weight: 20kg/drum
85% concentration: plastic drum with pallets, net weight: 20kg/drum
Customized Packaging: Customized packaging is available according to customer requirements.
Storage
Storage Conditions: Store in a cool, dry, and well-ventilated location, protected from light.
FAQ
Q: What is the chemical stability of TBAF?
A: It is relatively stable under dry conditions, but it should be kept away from high temperatures, strong acids, strong bases, and prolonged exposure to air to prevent decomposition or alterations in its chemical properties.
Q: In organic synthesis, what are its advantages compared to other protective reagents?
A: Compared to other protective reagents, Tetrabutylammonium fluoride trihydrate offers higher selectivity and efficiency, especially in the removal of silicon-based protective groups. It can effectively reduce side reactions.
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